Molecular machines governing exocytosis of synaptic vesicles
نویسندگان
چکیده
منابع مشابه
Cholesterol reduction impairs exocytosis of synaptic vesicles.
Cholesterol and sphingolipids are abundant in neuronal membranes, where they help the organisation of the membrane microdomains involved in major roles such as axonal and dendritic growth, and synapse and spine stability. The aim of this study was to analyse their roles in presynaptic physiology. We first confirmed the presence of proteins of the exocytic machinery (SNARES and Ca(v)2.1 channels...
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Wen-Pin Chang1 and Thomas C. Südhof1,2,3,4 Departments of 1Neuroscience and 2Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, 3Neuroscience Institute and Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Palo Alto, California 94304-5543, and 4Howard Hughes Medical Institute at University of Texas Southwestern M...
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The fusion of synaptic vesicles (SVs) with the plasma membrane of the active zone (AZ) upon arrival of an action potential (AP) at the presynaptic compartment is a tightly regulated probabilistic process crucial for information transfer. The probability of a SV to release its transmitter content in response to an AP, termed release probability (Pr), is highly diverse both at the level of entire...
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The cycle of a synaptic vesicle (SV) within the nerve terminal is a step-by-step journey with the final goal of ensuring the proper synaptic strength under changing environmental conditions. The SV cycle is a precisely regulated membrane traffic event in cells and, because of this, a plethora of membrane-bound and cytosolic proteins are devoted to assist SVs in each step of the journey. The cyc...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature11320